Using Autoimmunity To Inform Tumor Immunity.
نویسنده
چکیده
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منابع مشابه
Coupling and Uncoupling of Tumor Immunity and Autoimmunity
Self-antigens, in the form of differentiation antigens, are commonly recognized by the immune system on melanoma and other cancers. We have shown previously that active immunization of mice against the melanocyte differentiation antigen, a tyrosinase-related protein (TRP) gp75(TRP-1) (the brown locus protein) expressed by melanomas, could induce tumor immunity and autoimmunity manifested as dep...
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BACKGROUND Although the exact mechanisms mediating the initiation of autoimmune diseases are unknown, sequence similarity between infectious agents and self-proteins (epitope mimicry) has been proposed as the main trigger mechanism. Interestingly, this mechanism of epitope mimicry may also evoke potent tumor immunity. Indeed, experimental data support a beneficial role of autoimmunity in some p...
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عنوان ژورنال:
- Journal of immunology
دوره 195 11 شماره
صفحات -
تاریخ انتشار 2015